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April 21, 2014PLoS ONEOpen Access

An Analysis of the Global Expression of MicroRNAs in an Experimental Model of Physiological Left Ventricular Hypertrophy

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Why the study?

Does voluntary exercise alter global microRNA expression in a mouse model of physiological left ventricular hypertrophy?

Population

8 to 10 week-old male Balb/c mice (n=20-24)

Comparison

Voluntary exercise on odometer-monitored metal… vs Sedentary group kept in standard cages without…

Design

Preclinical, Echocardiographic operator was blinded to group allocation at all…

Follow-up

35 days

Authors

NMNidiane Carla MartinelliSan Diego State UniversityCCCarolina Rodrigues CohenKSKátia Gonçalves dos SantosUniversidade Federal do Rio Grande do Sul

Discussion

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Overview

Exercise-induced miRNA shifts in murine physiological LVH are hypothesis-generating; human translation and clinical relevance remain untested.

Structured PICO

Does voluntary exercise alter global microRNA expression in a mouse model of physiological left ventricular hypertrophy?

P
Population
8 to 10 week-old male Balb/c mice (n=20-24)
I
Intervention
Voluntary exercise on odometer-monitored metal wheels for 35 days
C
Comparator
Sedentary group kept in standard cages without exercise wheels
O
Outcome
Global microRNA (miR) expression and physiological left ventricular hypertrophy (LV weight/body weight ratio)surrogate

Physiological cardiac hypertrophy induced by exercise is associated with a distinct microRNA expression profile, particularly involving miR-26b, -150, -27a, and -143, which differs from established pathological LVH pathways.

Cite This Study

Martinelli et al. (2014) studied this question.

synapsesocial.com/papers/6a6fbddfa7fbea1e4407d626https://doi.org/10.1371/journal.pone.0093271
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