Why the study?
Does three cycles of CHOP plus radiotherapy improve progression-free and overall survival compared to eight cycles of CHOP alone in patients with localized intermediate- and high-grade non-Hodgkin's lymphoma?
Population
401 patients with clinically localized, intermediate- or high-grade non-Hodgkin's lymphoma
Comparison
Three cycles of CHOP followed by involved-field… vs Eight cycles of CHOP alone
Design
RCT, randomly assigned
Follow-up
5 years
Authors
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Supports abbreviated CHOP plus radiotherapy as preferred for localized aggressive NHL; extends evidence for combined-modality therapy over chemotherapy alone.
Does three cycles of CHOP plus radiotherapy improve progression-free and overall survival compared to eight cycles of CHOP alone in patients with localized intermediate- and high-grade non-Hodgkin's lymphoma?
Three cycles of CHOP followed by involved-field radiotherapy significantly improves progression-free and overall survival while reducing cardiotoxicity compared to eight cycles of CHOP alone in localized intermediate- and high-grade non-Hodgkin's lymphoma.
Miller et al. (1998) studied this question.
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