The regulation of actin polymerization in differentiating U937 cells correlates with increased membrane levels of the pertussis-toxin-sensitive G-protein Gi2
Population
U937 cells (undifferentiated and db-cAMP-differentiated)
Comparison
Treatment with dibutyryl cyclic AMP and… vs Undifferentiated U937 cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports Gi2 alpha in cytoskeletal signaling; hypothesis-generating for cardiovascular models and should not yet change practice.
Structured PICO
P
Population
U937 cells (undifferentiated and db-cAMP-differentiated)
I
Intervention
Treatment with dibutyryl cyclic AMP (db-cAMP) and guanosine 5'-[gamma-thio]trisphosphate (GTP[S])
C
Comparator
Undifferentiated U937 cells
O
Outcome
Actin polymerization (cellular F-actin increase) and membrane association levels of G-protein Gi2 alphasurrogate
Gi2 alpha may be involved in the signal-transduction pathway leading to actin polymerization in db-cAMP-differentiated U937 cells.
Cite This Study
Sheth et al. (1991) studied this question.