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January 1, 1987Cell Motility and the Cytoskeleton

Intracellular acidification, guanine‐nucleotide binding proteins, and cytoskeletal actin

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Population

Rabbit neutrophils

Comparison

Propionic acid, with or without pertussis toxin… vs Basal level / untreated cells

Design

Preclinical

Authors

TMThaddeus F. MolskiBristol-Myers Squibb (United States)RSR.I. Sha’afiBrigham and Women's Hospital

Discussion

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Implication

Acidification alone insufficient for actin response in neutrophils; leaves open G-protein requirement for cytoskeletal studies.

Structured PICO

P
Population
Rabbit neutrophils
I
Intervention
Propionic acid (and fMet-Leu-Phe), with or without pertussis toxin pretreatment
C
Comparator
Basal level / untreated cells
O
Outcome
Intracellular pH (acidification) and amount of cytoskeletal actinsurrogate

Cell acidification alone is insufficient for actin-cytoskeleton association; a functional G-protein is required for stimulated cytoskeletal actin in rabbit neutrophils.

Cite This Study

Molski et al. (1987) studied this question.

synapsesocial.com/papers/6a8957b71acf8e321fbd531dhttps://doi.org/10.1002/cm.970080102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Actin polymerization induced by chemotactic peptide and concanavalin A in rat neutrophils.1982 · 121 citations
  2. 2Effects of chemotactic factors and other agents on the amounts of actin and a 65,000-mol-wt protein associated with the cytoskeleton of rabbit and human neutrophils.1985 · 60 citations
  3. 3Stimulation by chemotactic factor of actin association with the cytoskeleton in rabbit neutrophils. Effects of calcium and cytochalasin B.1983 · 152 citations
  4. 4Intracellular pH Changes During Neutrophil Activation: Na+ /H+ Antiport1987 · 40 citations
  5. 5Chemotactic peptide-induced changes in neutrophil actin conformation.1984 · 185 citations