Time course of vasodilatory responses in skeletal muscle arterioles: role in hyperemia at onset of exercise

View Full Paper

Ask AI

Bookmark

Population

First-order arterioles isolated from soleus and gastrocnemius muscles of male Sprague-Dawley rats

Design

Preclinical

Authors

Discussion

Does not support local vasodilators initiating rapid exercise hyperemia; leaves open alternative mechanisms for human investigation.

Population

First-order arterioles (100-200 microm) isolated from soleus and gastrocnemius muscles of male Sprague-Dawley rats

Intervention

Direct application of potassium chloride, adenosine, acetylcholine, and sodium nitroprusside

Outcome

Time course of the vasodilatory response (diameter increases)surrogate

Local vasodilators do not act rapidly enough (<2 s) to initiate the exercise hyperemic response at the onset of dynamic exercise.

Wunsch et al. (2000) studied this question.

View Full Paper

Ask AI

Bookmark