Why the study?
Does ganglionic blockade prevent rapid vasodilation in active skeletal muscle at the onset of exercise in dogs?
Population
Mongrel dogs (n = 7) instrumented with flow probes on both external iliac arteries
Comparison
Intravenous infusion of hexamethonium and… vs Intravenous infusion of saline before treadmill…
Design
Preclinical
Authors
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Autonomic blockade spares early exercise hyperemia in dogs; leaves open local control mechanisms and human translation.
Does ganglionic blockade prevent rapid vasodilation in active skeletal muscle at the onset of exercise in dogs?
The autonomic nervous system is not essential for the rapid vasodilation in active skeletal muscle at the onset of exercise in dogs, but rather controls blood flow through vasoconstriction.
Buckwalter et al. (1999) studied this question.
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