Key result
Sympathetic ganglionic blockade and atropine blunted the initial increase in brachial vascular conductance at the onset of static exercise in conscious cats.
Population
6 conscious cats operantly conditioned to perform static bar press exercise with a forelimb
Comparison
Administration of sympathetic ganglionic… vs Baseline/unblocked state
Design
Preclinical
Authors
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Hypothesis-generating for sympathetic cholinergic vasodilation in exercise; extends animal models but leaves open human translation.
The sympathetic cholinergic mechanism contributes to muscle vasodilatation at the onset of voluntary static exercise in conscious cats.
Komine et al. (2008) studied this question. Sympathetic ganglionic blocker (hexamethonium bromide) and atropine sulfate or methyl nitrate vs. Baseline / no blocker was evaluated on Brachial blood flow and vascular conductance at the onset of static exercise. Sympathetic ganglionic blockade and atropine blunted the initial increase in brachial vascular conductance at the onset of static exercise in conscious cats.
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