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March 1, 2008Expert Opinion on Pharmacotherapy

Doxazosin in the current treatment of hypertension

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Why the study?

Does doxazosin as an add-on therapy improve blood pressure response in hypertensive patients?

Population

Hypertensive patients, including subgroups such as diabetics, the elderly, patients with benign prostatic…

Design

Review

Authors

AWAndrzej WykrętowiczPGPrzemysław GuzikHWHenryk Wysocki

Discussion

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Overview

Supports doxazosin add-on in hypertension with good tolerability; leaves open confirmation by randomized trials before changing practice.

Structured PICO

Does doxazosin as an add-on therapy improve blood pressure response in hypertensive patients?

P
Population
Hypertensive patients, including subgroups such as diabetics, the elderly, patients with benign prostatic hyperplasia or hypercholesterolaemia, the obese, or Afro-Americans
I
Intervention
Doxazosin (standard or extended-release formulation) as a second- or third-line add-on therapeutic agent to other antihypertensive drugs
O
Outcome
Blood pressure responsesurrogate

Doxazosin remains a valuable and effective add-on antihypertensive treatment option with a favorable side effect profile.

Limitations

  • The clinical role of 'beyond blood pressure' effects of doxazosin are largely undetermined.

Cite This Study

Wykrętowicz et al. (2008) studied this question.

synapsesocial.com/papers/6a6fce61a7fbea1e4407dabchttps://doi.org/10.1517/14656566.9.4.625
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Doxazosin as Combination Therapy for Patients with Stage 1 and Stage 2 Hypertension2003 · 26 citations
  2. 2Clinically additive effect between doxazosin and amlodipine in the treatment of essential hypertension2000 · 18 citations
  3. 3The Bedtime Administration of Doxazosin Controls Morning Hypertension and Albuminuria in Patients with Type-2 Diabetes: Evaluation Using Home-Based Blood Pressure Measurements2005 · 24 citations
  4. 4Blood Pressure Reduction Is Not the Only Determinant of Outcome2006 · 58 citations