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June 1, 2003Journal of Cardiovascular Pharmacology

Doxazosin as Combination Therapy for Patients with Stage 1 and Stage 2 Hypertension

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Why the study?

Does doxazosin as combination therapy improve blood pressure in patients with stage 1 and stage 2 hypertension?

Population

Patients with stage 1 and stage 2 hypertension, including those with inadequately controlled hypertension…

Comparison

Doxazosin as combination therapy vs Placebo

Design

Review

Authors

HBHenry R. Black

Discussion

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Overview

May support doxazosin add-on in hypertension with lipid effects; leaves open randomized confirmation.

Structured PICO

Does doxazosin as combination therapy improve blood pressure in patients with stage 1 and stage 2 hypertension?

P
Population
Patients with stage 1 and stage 2 hypertension, including those with inadequately controlled hypertension and those with concomitant hyperlipidemia or glucose intolerance
I
Intervention
Doxazosin as combination therapy
C
Comparator
Placebo
O
Outcome
Sitting and standing blood pressuresurrogate

Doxazosin is an effective and well-tolerated combination therapy for stage 1 and 2 hypertension, offering additional benefits for patients with concomitant hyperlipidemia or glucose intolerance.

Cite This Study

Henry R. Black (2003) studied this question.

synapsesocial.com/papers/6a72b3166c240de38cdc71a1https://doi.org/10.1097/00005344-200306000-00006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinically additive effect between doxazosin and amlodipine in the treatment of essential hypertension2000 · 18 citations
  2. 2The Addition of Doxazosin to the Therapeutic Regimen of Hypertensive Patients Inadequately Controlled with Other Antihypertensive Medications: A Randomized, Placebo-Controlled Study2000 · 50 citations
  3. 3Combination of Nifedipine and Doxazosin in Essential Hypertension1992 · 44 citations
  4. 4Comparative and Combined Efficacy of Doxazosin and Enalapril in Hypertensive Patients1994 · 9 citations
  5. 5The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure1997 · 5,667 citations