October 11, 2005ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)
Diagnostic potential of circulating natriuretic peptides in chronic kidney disease
Why the study?
Does the measurement of circulating natriuretic peptides accurately diagnose LV hypertrophy and dysfunction in patients with chronic kidney disease?
Population
296 patients with renal disease but no history of cardiac disease
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Caution against unadjusted BNP for LV dysfunction diagnosis in CKD; leaves open GFR-adjusted thresholds in prospective validation.
Structured PICO
Does the measurement of circulating natriuretic peptides accurately diagnose LV hypertrophy and dysfunction in patients with chronic kidney disease?
P
Population
296 patients with renal disease but no history of cardiac disease
I
Intervention
Measurement of circulating levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP)
O
Outcome
Sensitivity and specificity of ANP and BNP for LV hypertrophy and LV dysfunction, and correlation with GFRsurrogate
In patients with chronic kidney disease, GFR significantly confounds BNP levels, limiting the diagnostic utility of natriuretic peptides for left ventricular dysfunction.
Cite This Study
Mark et al. (2005) studied this question.