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June 1, 2009Postgraduate Medical Journal

Most studies indicate that upward adjustment of diagnostic cut points preserves the usefulness of both BNP and NT-proBNP in the CKD patient, with similar clinical performance of each biomarker.

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Why the study?

Are natriuretic peptides (BNP and NT-proBNP) useful for diagnosing heart failure in patients with chronic kidney disease?

Population

Patients with chronic kidney disease (CKD) being evaluated for heart failure

Design

Review

Authors

SDSandipan DharGPGregg S. PressmanSSSreekumar Subramanian

Discussion

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Overview

Adjusted BNP/NT-proBNP thresholds may aid HF diagnosis in CKD; leaves open prospective validation before practice change.

Structured PICO

Are natriuretic peptides (BNP and NT-proBNP) useful for diagnosing heart failure in patients with chronic kidney disease?

P
Population
Patients with chronic kidney disease (CKD) being evaluated for heart failure
I
Intervention
Natriuretic peptides (BNP and NT-proBNP) testing with upward adjustment of diagnostic cut points
O
Outcome
Diagnosis or exclusion of heart failuresurrogate

In patients with chronic kidney disease, BNP and NT-proBNP remain useful for diagnosing heart failure when diagnostic cut points are adjusted upward.

Cite This Study

Dhar et al. (2009) studied this question.

synapsesocial.com/papers/6a79d727e357fbdac5893cbfhttps://doi.org/10.1136/pgmj.2008.073734
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