January 20, 2021Molecular Medicine ReportsOpen Access

Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats

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Why the study?

Allisartan isoproxil is an ARB precursor drug used for hypertension, but its effects on diabetic cardiomyopathy and the roles of hyperglycaemia-induced oxidative stress and inflammation remained to be explored.

Does allisartan isoproxil improve cardiac function and attenuate oxidative stress and inflammation in a rat model of diabetic cardiomyopathy?

Population

Rat model of diabetic cardiomyopathy induced by high-fat diet and streptozocin injection

Comparison

Allisartan isoproxil vs untreated diabetic controls

Design

Preclinical animal study

Authors

QJQinyang JinZhejiang Provincial People's Hospital QZQin ZhuZhejiang Chinese Medical University KWKai WangInstitute of Environmental Studies & Wetland Management

Discussion

Member takes

Implication

Allisartan isoproxil mitigated DCM features in rats; leaves open translation to human diabetic cardiomyopathy.

Structured PICO

Does allisartan isoproxil improve cardiac function and attenuate oxidative stress and inflammation in a rat model of diabetic cardiomyopathy?

Population

32 adult Sprague-Dawley rats weighing 280-300 g, with diabetic cardiomyopathy induced by high-fat diet and streptozocin injection.

Intervention

Allisartan isoproxil 10.8 mg/kg/day for 8 weeks

Comparator

PBS (DCM+PBS group) and no treatment (DCM group), as well as a non-diabetic control group fed a normal diet

Outcome

Cardiac function (EF, FS, E'/A' ratio), histological alterations, and expression of oxidative stress and inflammatory markerssurrogate

Allisartan isoproxil attenuates diabetic cardiomyopathy in rats by reducing oxidative stress and inflammation via the SIRT1/Nrf2/NF-κB pathway.

Limitations

neglected to set a positive reference group

Cite This Study

Jin et al. (2021) studied this question.

synapsesocial.com/papers/6a6fd327f44fa9f079dd51fc https://doi.org/10.3892/mmr.2021.11854

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Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider