Why the study?
Does adenoviral-mediated gene transfer of eNOS to the carotid sinus adventitia modulate baroreceptor activity in rabbits?
Population
Anesthetized rabbits (n=15)
Comparison
Adenoviral vectors encoding endothelial type III… vs Adenoviral vectors encoding beta-galactosidase…
Design
Preclinical
Follow-up
4 to 5 days
Authors
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No direct clinical implications; extends preclinical evidence for NO-mediated baroreceptor resetting in animal models.
Does adenoviral-mediated gene transfer of eNOS to the carotid sinus adventitia modulate baroreceptor activity in rabbits?
Adenoviral-mediated gene transfer of eNOS to the carotid sinus adventitia causes sustained, NO-dependent inhibition of baroreceptor activity and resets the baroreceptor function curve to higher pressures.
Meyrelles et al. (2003) studied this question.
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