Why the study?
The study was conducted to evaluate the correlation between left ventricular hypertrophy and the gene polymorphisms of ACE intron deletion (I/D) and ACE G2350A.
Are ACE intron deletion (I/D) and ACE G2350A gene polymorphisms associated with an increased risk of left ventricular hypertrophy?
Are ACE intron deletion (I/D) and ACE G2350A gene polymorphisms associated with an increased risk of left ventricular hypertrophy?
The D allele of ACE I/D and the A allele of ACE G2350A are genetic risk factors associated with an increased risk of left ventricular hypertrophy.
OBJECTIVES: The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. METHODS: Information related to the sample size and genotype frequencies was extracted from each study. RESULTS: Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. CONCLUSIONS: Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy.
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Fajar et al. (2019) studied this question.
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