August 18, 2020Biochemical and Biophysical Research CommunicationsOpen Access

The crystal structure of the emerging human-infecting hepatitis E virus E2s protein

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Why the study?

HEV species C was reported to infect humans in December 2018, unlike all previously known human-infecting variants belonging to species A.

Population

HEV-C E2s domain

Design

Structural and antibody binding study

Authors

CBChongzhi BaiGuangdong Pharmaceutical University JCJian‐Piao CaiUniversity of Hong Kong PHPengcheng HanShanxi Agricultural University

Discussion

Member takes

Implication

Atomic model of HEV-C E2s now available; leaves open whether it guides vaccine or antiviral design against zoonotic strains.

Structured PICO

Population

Hepatitis E virus species C (HEV-C) E2s domain

Intervention

Crystal structure determination and antibody binding experiments

Comparator

HEV-A E2s domain

Outcome

Crystal structure at 1.8 Å resolution and binding to antibodies 8G12 and 8C11surrogate

The crystal structure of the HEV-C E2s domain provides insights into host recognition and entry mechanisms, aiding the development of therapeutic antibodies and vaccines.

Cite This Study

Bai et al. (2020) studied this question.

synapsesocial.com/papers/6a6fdc9da528af2d65c332c7 https://doi.org/10.1016/j.bbrc.2020.07.074

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The crystal structure of the emerging human-infecting hepatitis E virus E2s protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The crystal structure of the emerging human-infecting hepatitis E virus E2s protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider