Key result
Structural analysis of HEV capsid proteins expressed in insect cells revealed that RNA binding is an extrinsic factor essential for the assembly of HEV native capsids.
Population
Insect cells expressing Hepatitis E virus (HEV) capsid protein (with and without N-terminal 111 residues)
Comparison
Expression of HEV capsid protein with N-terminal… vs Expression of HEV capsid protein without…
Design
Preclinical
Authors
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RNA binding offers a potential target to disrupt HEV capsid assembly; leaves open translation from insect-cell models to therapeutics.
RNA binding is an extrinsic factor essential for the assembly of Hepatitis E virus native capsids.
Li et al. (2010) studied Hepatitis E virus (HEV). Expression of HEV capsid protein with and without N-terminal 111 residues was evaluated on Capsid structure and assembly pathway. Structural analysis of HEV capsid proteins expressed in insect cells revealed that RNA binding is an extrinsic factor essential for the assembly of HEV native capsids.
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