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October 1, 1997Journal of VirologyOpen Access

Expression and self-assembly of empty virus-like particles of hepatitis E virus

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Population

Insect Tn5 cells

Design

Preclinical

Authors

TLTin Chiu LiRoyal College of Obstetricians and GynaecologistsYYYoshio YamakawaNational Institute of Health SciencesKSKazuyuki SuzukiIwate Medical University

Discussion

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Implication

May support HEV VLP research production; leaves open diagnostic or vaccine translation pending validation.

Structured PICO

P
Population
Insect Tn5 cells
I
Intervention
Expression of truncated HEV structural protein (amino acid residues 112 to 660 of ORF2) by a recombinant baculovirus
O
Outcome
Production and self-assembly of empty virus-like particles (VLPs)surrogate

Recombinant HEV structural protein expressed in insect cells self-assembles into highly immunogenic virus-like particles, offering a promising candidate for HEV diagnostics and vaccines.

Cite This Study

Li et al. (1997) studied this question.

synapsesocial.com/papers/6a8801824c82be800eeb3866https://doi.org/10.1128/jvi.71.10.7207-7213.1997
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ELISA for Antibody to Hepatitis E Virus (HEV) Based on Complete Open-Reading Frame-2 Protein Expressed in Insect Cells: Identification of HEV Infection in Primates1993 · 220 citations
  2. 2An Indian strain of hepatitis E virus (HEV): cloning, sequence, and expression of structural region and antibody responses in sera from individuals from an area of high-level HEV endemicity1995 · 96 citations
  3. 3Expression of rotavirus VP2 produces empty corelike particles1991 · 191 citations
  4. 4Evidence for a Virus in Non-A, Non-B Hepatitis Transmitted via the Fecal-Oral Route1983 · 906 citations
  5. 5Assembly of empty capsids by using baculovirus recombinants expressing human parvovirus B19 structural proteins1991 · 143 citations