Why the study?
Does glibenclamide act as an antagonist of the thromboxane A2 receptor in dog coronary arteries in vitro?
Population
Isolated ring segments of the large circumflex coronary artery from the dog
Comparison
Glibenclamide (1-30 microM) vs null
Design
Preclinical
Authors
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May influence interpretation of glibenclamide in vascular studies; leaves open translational relevance beyond canine coronary arteries in vitro.
Does glibenclamide act as an antagonist of the thromboxane A2 receptor in dog coronary arteries in vitro?
Glibenclamide acts as a competitive antagonist of the thromboxane A2 receptor in dog coronary arteries, an additional property to consider in smooth muscle studies.
Cocks et al. (1990) studied this question.
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