April 1, 1992Journal of Cardiovascular Pharmacology

Inhibition by Glibenclamide of Negative Chronotropic and Inotropic Responses to Pinacidil, Acetylcholine, and Adenosine in the Isolated Dog Heart

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Population

Isolated, blood-perfused canine atrium or ventricle

Comparison

Glibenclamide administered with pinacidil… vs Responses to pinacidil, acetylcholine, or…

Design

Preclinical

Authors

MMMakoto MurakamiJapan Agency for Medical Research and Development YFYasuyuki FurukawaNational Institute of Advanced Industrial Science and Technology YKYasuyuki KarasawaShinshu University

Discussion

Member takes

Implication

Provides mechanistic insight into KATP modulation in isolated hearts; leaves open translation to in vivo or clinical settings.

Structured PICO

Population

Isolated, blood-perfused canine atrium or ventricle

Intervention

Glibenclamide (0.1-3 mumol) administered with pinacidil, acetylcholine, or adenosine

Comparator

Responses to pinacidil, acetylcholine, or adenosine alone

Outcome

Chronotropic (sinus rate) and inotropic (contractile force) responsessurrogate

Glibenclamide selectively antagonizes the negative chronotropic and inotropic effects of the ATP-sensitive K+ channel opener pinacidil in the isolated dog heart.

Cite This Study

Murakami et al. (1992) studied this question.

synapsesocial.com/papers/6a885f6417733fb165eb3557 https://doi.org/10.1097/00005344-199204000-00020

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Inhibition by Glibenclamide of Negative Chronotropic and Inotropic Responses to Pinacidil, Acetylcholine, and Adenosine in the Isolated Dog Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition by Glibenclamide of Negative Chronotropic and Inotropic Responses to Pinacidil, Acetylcholine, and Adenosine in the Isolated Dog Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider