August 1, 1994Circulation Research
Glibenclamide enhances but pinacidil reduces attenuation in sympathetic responsiveness after acute coronary artery occlusion.
Why the study?
Does modulation of ATP-sensitive K+ channels with glibenclamide or pinacidil alter the attenuation in efferent cardiac sympathetic responsiveness following acute myocardial ischemia/infarction in anesthetized dogs?
Population
Anesthetized dogs undergoing acute coronary artery occlusion, n=67.
Comparison
Glibenclamide or pinacidil administered… vs Intravenous vehicle.
Design
Preclinical
Follow-up
3 hours
Authors
Discussion
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Implication
KATP modulation alters post-MI sympathetic attenuation in dogs; hypothesis-generating for human arrhythmia mechanisms.
Structured PICO
Does modulation of ATP-sensitive K+ channels with glibenclamide or pinacidil alter the attenuation in efferent cardiac sympathetic responsiveness following acute myocardial ischemia/infarction in anesthetized dogs?
P
Population
Anesthetized dogs undergoing acute coronary artery occlusion (latex injection of a diagonal branch of the left anterior descending coronary artery), n=67.
I
Intervention
Glibenclamide (ATP-sensitive K+ channel blocker) or pinacidil (ATP-sensitive K+ channel opener) administered intravenously at various doses.
C
Comparator
Intravenous vehicle.
O
Outcome
Cumulative attenuation in sympathetic responsiveness (shortening of effective refractory period ≤ 2 milliseconds induced by bilateral stimulation of the ansae subclaviae) at nonischemic test sites apical to the area of ischemia/infarction during a 3-hour period.surrogate
In a canine model of acute myocardial infarction, blocking ATP-sensitive K+ channels with glibenclamide enhances, while opening them with pinacidil reduces, the attenuation of sympathetic responsiveness.
Cite This Study
Ito et al. (1994) studied this question.