Key result
Glibenclamide specifically antagonized the negative inotropic effects of potassium channel openers cromakalim, pinacidil, and nicorandil in canine atrial muscle, yielding pA2 values of 6.06 to 6.35.
Population
Canine right atrial muscle preparations from mongrel dogs (5-13 kg, either sex)
Comparison
Glibenclamide administered 20 min before… vs Control muscles run in parallel without…
Design
Preclinical
Authors
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Glibenclamide selectively antagonizes K+ opener effects in canine atrium; leaves open translation to human cardiac electrophysiology or therapy.
Effect estimate: pA2 6.06-6.35
Glibenclamide specifically antagonizes the negative inotropic effects of potassium channel openers in canine atrial muscle, suggesting competition at the ATP-sensitive potassium channel.
Satoh et al. (1990) studied Healthy canine atrial muscle. Glibenclamide vs. Control (no glibenclamide) was evaluated on Antagonism of negative inotropic effects of potassium channel openers (pA2 values) (pA2 6.06-6.35). Glibenclamide specifically antagonized the negative inotropic effects of potassium channel openers cromakalim, pinacidil, and nicorandil in canine atrial muscle, yielding pA2 values of 6.06 to 6.35.
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