Why the study?
Does the combination of patient age and estimated plasma volume predict initial antifactor Xa activity better than patient weight alone in patients receiving unfractionated heparin?
Does the combination of patient age and estimated plasma volume predict initial antifactor Xa activity better than patient weight alone in patients receiving unfractionated heparin?
Patient age and estimated plasma volume predict initial antifactor Xa activity better than weight alone, suggesting standard weight-based unfractionated heparin dosing may be suboptimal.
May refine initial heparin dosing beyond weight; hypothesis-generating and requires prospective validation before practice change.
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Terry K. Rosborough (1998) studied this question.
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