Why the study?
What is the required dose of unfractionated heparin to achieve intermediate intensity antifactor Xa concentrations in pregnant women?
What is the required dose of unfractionated heparin to achieve intermediate intensity antifactor Xa concentrations in pregnant women?
Pregnant women require a mean UFH dose of 236.9 units/kg/day to achieve intermediate-intensity antifactor Xa levels (0.1-0.3 unit/ml), with dose requirements correlating with patient weight.
Weight-adjusted UFH dosing may be needed in pregnancy; this Level 3 cohort study leaves open the need for prospective validation.
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Clark et al. (2010) studied this question.
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