Why the study?
Does the APTT response to unfractionated heparin differ in pregnant women compared to non-pregnant women?
Population
13 pregnant women (third trimester) and 15 nonpregnant women (n=28)
Comparison
Unfractionated heparin added in vitro to… vs Plasma from non-pregnant women
Design
Other
Authors
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Standard APTT targets may risk UFH overdosing in pregnancy; hypothesis-generating and requires prospective validation.
Does the APTT response to unfractionated heparin differ in pregnant women compared to non-pregnant women?
Pregnant women have an attenuated APTT response to unfractionated heparin due to increased protein binding, indicating that standard non-pregnant APTT targets may lead to systematic overdosing.
Young et al. (2002) studied this question.
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