Why the study?
Do heparinized polyurethane catheters reduce thrombus formation compared to untreated catheters in a canine model?
Do heparinized polyurethane catheters reduce thrombus formation compared to untreated catheters in a canine model?
Heparin-immobilized and heparin-releasing polyurethane catheters significantly reduce thrombus formation compared to untreated catheters in a canine model.
Supports heparinized catheter development; leaves open translation from canine models to clinical use.
Heparin - immobilized polyurethane (HI-PU) catheters implanted in canine femoral and jugular veins for one hour periods exhibited significant reduction in thrombus formation compared with untreated PU contralateral controls. PU catheters coated with a 9% heparin dispersion in PU, capable of releasing active heparin for several hours, provided even greater improvement in antithrombogenicity. Both types of heparinized surface displayed reduced platelet aggregation and fibrin formation, although platelet adhesion was somewhat higher on the HI material than on the heparin-releasing (HR) surface.
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Heyman et al. (1985) studied this question.
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