Key result
Heparin-bound polyurethanes improve blood-compatibility through specific heparinization methods and interactions with blood coagulation factors, plasma proteins, and platelets.
This review outlines the methods for creating heparin-bound polyurethanes and their mechanisms for improving blood compatibility.
Many kinds of heparin-bound polyurethanes have been developed. Polyurethanes are a family of elastomers displaying better blood-compatibility than other polymeric materials. It is useful to modify this material by heparinization. Several approaches to heparinization have been devised: 1) a general method of heparinization, applicable to all polymeric materials, 2) a heparinization method specific to polyurethanes, and 3) the design of heparinizable polyurethane derivatives. These three approaches are first explained in detail. Then, the antithrombogenic mechanism of the heparinized polymers is discussed. Finally, the interactions of the heparinized polymers with blood coagulation factors, plasma proteins, and platelets are discussed.
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Yoshihiro Ito (1987) reported a review. Heparin-bound polyurethanes was evaluated. Heparin-bound polyurethanes improve blood-compatibility through specific heparinization methods and interactions with blood coagulation factors, plasma proteins, and platelets.
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