Key result
Porous polyurethane coatings increase heparin binding and elution versus smooth coatings, especially after longer soaking.
Why the study?
Does porous polyurethane coating increase heparin binding capacity compared to smooth coating on metal carriers?
Does porous polyurethane coating increase heparin binding capacity compared to smooth coating on metal carriers?
Porous polyurethane coatings on metal stent materials demonstrate superior heparin binding capacity compared to smooth coatings, which increases with longer soaking times.
May inform heparin-eluting device design; leaves clinical translation and durability open.
In this article the investigation of heparin binding capacity of three biocompatible polyurethane coating are shown. The polyurethanes as coating on metal carrier were studied. The heparin binding capacity has measured by Optical Waveguide Lightmode Spectroscopy (OWLS) that measure the heparin elution.I have studied which type of polyurethane coated the most heparin. The heparin binding capacity was compared of smooth, porous-free, and porous coating. The porous coating had higher heparin binding capacity than the smooth coating. Furthermore it was studied, if the heparin soaking time is increased in case of the porous coating, the heparin absorption is increased too. It was also concluded, that the increase of the time of the heparin soaking cause increase of heparin absorption.
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Liza Pelyhe (2010) studied Coronary artery disease (stent coating development). Porous polyurethane coating vs. Smooth polyurethane coating was evaluated on Heparin binding capacity and elution. Porous polyurethane coatings demonstrated higher heparin binding capacity and elution compared to smooth coatings, with binding increasing after longer soaking times.
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