New segmented polyurethanes were synthesized and shown to bind high amounts of heparin with retained biological activity in vitro, suggesting potential utility as biomedical compositions.
The synthesis of new segmented polyurethanes containing different amounts of N,N‐diethylaminoethyl‐N′‐2,2 hydroxymethylpropionamide, and able to bind, after suitable quaternization, high amounts of heparin, is described. The quaternization is carried out on organic solutions of the polymers. Polymers have been characterized by spectroscopic techniques (transmission and reflectance IR and 1 H and 13 C NMR), molecular weight measurements and differential scanning calorimetry. The heparin content of the polymer films was determined by a colorimetric system, and its biological activity was evaluated in vitro by activated partial thromboplastin time (APTT) measurements. The distribution of heparin on the surface and in bulk of the heparinized films was evaluated by scanning electron microscopy (SEM) combined with X‐ray energy dispersive spectroscopy.
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Marconi et al. (1993) studied this question.
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