Why the study?
Does heparin and low molecular weight heparin augment vascular endothelial barrier function in human umbilical vein endothelial cells?
Population
Early passage human umbilical vein endothelial cells grown to confluence on transparent micropore filters
Comparison
Unfractionated heparin and low molecular weight… vs Untreated control cells (implied)
Design
Preclinical
Authors
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May support heparin's barrier role in resting endothelium in vitro; leaves open in vivo relevance and clinical translation.
Does heparin and low molecular weight heparin augment vascular endothelial barrier function in human umbilical vein endothelial cells?
Heparin and LMW heparin enhance the barrier function of resting endothelium in vitro but cannot fully reverse IL-1-induced permeability or replace endogenous glycosaminoglycans.
Bannon et al. (1995) studied this question.
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