Why the study?
Are there regional differences in blood flow that explain the lack of correlation between cardiac output and exercise tolerance in patients with chronic heart failure compared to healthy controls?
Population
30 patients with chronic heart failure and 10 healthy controls
Design
Case-control
Authors
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Regional hypoperfusion may limit exercise tolerance in HF beyond central output; hypothesis-generating for peripheral-targeted therapies.
Are there regional differences in blood flow that explain the lack of correlation between cardiac output and exercise tolerance in patients with chronic heart failure compared to healthy controls?
Reduced regional blood flow to skeletal muscle and kidneys, rather than central cardiac output alone, may determine exercise intolerance in chronic heart failure.
Muller et al. (1992) studied this question.
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