August 4, 2005Journal of the American Society of NephrologyOpen Access

Disparity in Osmolarity-Induced Vascular Reactivity

View Full Paper

Ask AI

Bookmark

Population

Anesthetized nonheparinized rats and rat endothelium-intact and -denuded aortic rings

Comparison

Filter-sterilized isotonic and hypertonic… vs Clinical peritoneal dialysis solution

Design

Preclinical

Authors

EZEl Rasheid ZakariaFundación Juan March CHCatherine HuntNorth Cumbria Integrated Care NHS Foundation Trust NLNa LiAnhui Medical University

Discussion

Member takes

Implication

Animal data on peritoneal dialysis solution vasoactivity; leaves open translation to human outcomes.

Structured PICO

Population

Anesthetized nonheparinized rats (in vivo jejunum microvasculature) and rat endothelium-intact and -denuded aortic rings (ex vivo)

Intervention

Filter-sterilized isotonic and hypertonic solutions containing glucose or mannitol, and lactate in low-pH isotonic physiologic salt solution

Comparator

Clinical peritoneal dialysis solution (Delflex 2.25%)

Outcome

Vascular reactivity (vasodilation, relaxation, and force generation)surrogate

Hyperosmolality and lactate are the primary vasoactive components of peritoneal dialysis solutions, with glucose mediating vasodilation via adenosine receptors.

Cite This Study

Zakaria et al. (2005) studied this question.

synapsesocial.com/papers/6a6fead0e71d69abee08451f https://doi.org/10.1681/asn.2004090764

View Full Paper

Ask AI

Bookmark

Disparity in Osmolarity-Induced Vascular Reactivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Disparity in Osmolarity-Induced Vascular Reactivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider