October 1, 1993British Journal of PharmacologyOpen Access

Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation

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Population

Pentobarbitone-anaesthetized pigs

Design

Preclinical

Authors

KAKjell AlvingUppsala University CFC. FORNHEM JLJan M. LundbergAstraZeneca (United Kingdom)

Discussion

Member takes

Implication

Animal data implicate NO in smoke-induced bronchial vasodilatation; hypothesis-generating and should not yet influence clinical management.

Structured PICO

Population

Pentobarbitone-anaesthetized pigs

Intervention

Inhalation of cigarette smoke (unfiltered or filtered), nicotine aerosol, nitric oxide (NO), carbon monoxide (CO), and intravenous NG-nitro-L-arginine (L-NOARG; 50 mg kg-1)

Outcome

Changes in bronchial, pulmonary, and femoral vascular resistance, pulmonary airways resistance (Rpulm), and lung dynamic compliance (Cdyn)surrogate

In a pig model, nitric oxide present in cigarette smoke is the primary mediator of smoke-induced bronchial and pulmonary vasodilatation, while endogenous NO regulates basal bronchial vascular tone.

Cite This Study

Alving et al. (1993) studied this question.

synapsesocial.com/papers/6a6fec06c92390ac2d07aeba https://doi.org/10.1111/j.1476-5381.1993.tb13874.x

View Full Paper

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Implication

Animal data implicate NO in smoke-induced bronchial vasodilatation; hypothesis-generating and should not yet influence clinical management.

Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pulmonary effects of endogenous and exogenous nitric oxide in the pig: relation to cigarette smoke inhalation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider