Key result
In anesthetized pigs, endothelial nitric oxide synthase stimulation by acetylcholine lowered mean arterial pressure by 15% and enhanced L-NMMA-induced pulmonary hypertension, which was abolished by indomethacin.
Why the study?
The differential effects of inhibiting endothelial nitric oxide synthase on systemic and pulmonary circulation in vivo were not fully understood.
RCT (n=17)
Randomized
No
Porcine model implicates prostaglandins in differential pulmonary-systemic responses to NOS inhibition; leaves open human relevance and therapeutic translation.
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Dahm et al. (1997) conducted an RCT in Healthy (Experimental Model) (n=17). Acetylcholine and L-NMMA (with or without indomethacin) vs. L-NMMA without acetylcholine was evaluated on Changes in mean arterial pressure and pulmonary arterial pressure. In anesthetized pigs, endothelial nitric oxide synthase stimulation by acetylcholine lowered mean arterial pressure by 15% and enhanced L-NMMA-induced pulmonary hypertension, which was abolished by indomethacin.
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