July 1, 1998Acta Physiologica Scandinavica

Role of nitric oxide in the regulation of regional blood flow and metabolism in anaesthetized pigs

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Population

Isoflurane anaesthetized pigs

Design

Preclinical

Authors

MLMarc LickerUniversity of Geneva HBH. BoussairiUniversity Hospital of Geneva LHLaurent HöhnUniversity Hospital of Geneva

Discussion

Member takes

Implication

Greater pulmonary vs systemic NO sensitivity in pigs; leaves open translation to human vascular regulation.

Structured PICO

Population

Isoflurane anaesthetized pigs

Intervention

N omega-L-arginine-methyl ester (L-NAME) in incremental doses (1, 3, 10, 30 and 100 mg kg-1, intravenously)

Outcome

Regional blood flow and metabolism (pressor effects, cardiac output distribution, and O2 uptake)surrogate

In anaesthetized pigs, endogenous nitric oxide plays a critical role in regulating pulmonary and renal blood flows, and its inhibition increases intestinal oxygen uptake despite unchanged global metabolic demand.

Cite This Study

Licker et al. (1998) studied this question.

synapsesocial.com/papers/6a70975635aa2c282ce1e9bd https://doi.org/10.1046/j.1365-201x.1998.t01-1-00396.x

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Role of nitric oxide in the regulation of regional blood flow and metabolism in anaesthetized pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of nitric oxide in the regulation of regional blood flow and metabolism in anaesthetized pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider