Value of Electrocardiographic Parameters and Ajmaline Test in the Diagnosis of Brugada Syndrome Caused by SCN5A Mutations
Why the study?
Does intravenous ajmaline testing accurately identify SCN5A mutation carriers in families with Brugada syndrome?
Population
147 individuals representing 4 large families with SCN5A mutations, of which 104 were determined to be at…
Comparison
Intravenous ajmaline test vs Genetic testing for SCN5A mutation
Design
Cross-sectional
Authors
Discussion
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Implication
Ajmaline challenge may aid SCN5A carrier detection in Brugada families with nondiagnostic ECG; leaves open need for prospective validation before guiding management.
Structured PICO
Does intravenous ajmaline testing accurately identify SCN5A mutation carriers in families with Brugada syndrome?
P
Population
147 individuals representing 4 large families with SCN5A mutations, of which 104 were determined to be at possible risk for Brugada syndrome and underwent both electrocardiographic and genetic evaluation.
I
Intervention
Intravenous ajmaline test
C
Comparator
Genetic testing for SCN5A mutation (reference standard)
O
Outcome
Diagnostic accuracy (sensitivity, specificity, positive and negative predictive values) of the ajmaline test for identifying SCN5A mutation carrierssurrogate
Intravenous ajmaline testing is highly specific and has good sensitivity for identifying SCN5A mutation carriers in families with Brugada syndrome, particularly when baseline ECG is non-diagnostic but shows first-degree atrioventricular block.
Cite This Study
Hong et al. (2004) studied this question.