Key result
A standardized ajmaline challenge using fractionated intravenous administration safely unmasked Brugada syndrome in 23% of patients, with symptomatic ventricular tachycardia occurring in only 1.3%.
Why the study?
Does a standardized fractionated ajmaline challenge safely unmask the diagnostic ECG pattern in patients suspected of Brugada syndrome?
Population
n=158 patients undergoing evaluation for Brugada syndrome, including those with unexplained syncope and…
Design
Cohort
Follow-up
Acute (during the test)
Authors
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Supports fractionated ajmaline safety for Brugada unmasking; hypothesis-generating and requires randomized trials before practice change.
Observational (n=158)
No
Does a standardized fractionated ajmaline challenge safely unmask the diagnostic ECG pattern in patients suspected of Brugada syndrome?
A standardized ajmaline challenge with fractionated intravenous administration is a safe and effective method to unmask Brugada syndrome, though it carries a small risk of inducing ventricular tachycardia requiring continuous medical surveillance.
Sascha Rolf (2003) conducted an observational in Brugada syndrome (n=158). Ajmaline challenge was evaluated on Unmasking of typical coved-type ECG pattern of Brugada syndrome. A standardized ajmaline challenge using fractionated intravenous administration safely unmasked Brugada syndrome in 23% of patients, with symptomatic ventricular tachycardia occurring in only 1.3%.
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