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February 1, 2014Open HeartOpen Access

Feasibility and outcomes of ajmaline provocation testing for Brugada syndrome in children in a specialist paediatric inherited cardiovascular diseases centre

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Why the study?

Is ajmaline provocation testing safe and feasible for diagnosing Brugada syndrome in children?

Population

95 children evaluated for family history of Brugada syndrome, family history of unexplained sudden cardiac…

Design

Cohort

Follow-up

mean 3.62 years

Authors

MMMerlin McMillanHospital do DesterroTDThomas G. DayKing's College LondonMBMargarita BartsotaRoyal Brompton Hospital

Discussion

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Implication

Supports safe ajmaline testing in specialist pediatric settings; leaves open age-related changes in test positivity.

Structured PICO

Is ajmaline provocation testing safe and feasible for diagnosing Brugada syndrome in children?

P
Population
95 children evaluated for family history of Brugada syndrome (n=46, 48%), family history of unexplained sudden cardiac death (n=39, 41%), or symptoms with suspicious ECG abnormalities (n=9, 10%), mean age 12.55 years, 43% female.
I
Intervention
Ajmaline provocation testing
O
Outcome
Safety and feasibility (occurrence of arrhythmias or adverse events during testing, and test positivity)safety

Ajmaline provocation testing for Brugada syndrome is safe and feasible in children when performed in a specialist setting, though test positivity may change with age.

Cite This Study

McMillan et al. (2014) studied this question.

synapsesocial.com/papers/6a75908cc0eb2bcc54e71ee0https://doi.org/10.1136/openhrt-2013-000023
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  5. 5Genetics and cardiovascular disease—causes and prevention of unexpected sudden adult death: the role of the SADS clinic2011 · 48 citations