What question did this study set out to answer?

To evaluate serum concentrations of nitric oxide and endothelin-1 as prospective biomarkers for predicting functional outcomes in acute ischemic stroke patients with varying neurological severity.

September 23, 2023General ReanimatologyOpen Access

The Role of Endothelinergic and Nitroxidergic Reactions in Predicting the Functional Outcome in Patients with Ischemic Stroke of Different Severity

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Why the study?

The study aimed to assess the value of nitric oxide (NO) and endothelin-1 (ET-1) serum concentrations as potential biomarkers for predicting functional outcomes in acute ischemic stroke.

Do NO and ET-1 serum concentrations predict functional outcome in patients with acute ischemic stroke?

Population

37 patients diagnosed with ischemic stroke admitted to a multidisciplinary vascular center

Comparison

Patients with NIHSS scores 15 (Group 1) vs NIHSS scores 15 (Group 2)

Follow-up

Day 10 of hospital stay

Authors

ATA. M. TynterovaImmanuel Kant Baltic Federal University EMEkaterina MoiseevaImmanuel Kant Baltic Federal University АГА. М. ГолубевV.A. Negovsky Scientific Research Institute of General Reanimatology

Discussion

Member takes

Implication

NO and ET-1 levels may predict stroke outcome; leaves open their biomarker utility pending larger validation studies.

Key Points

To evaluate serum concentrations of nitric oxide and endothelin-1 as prospective biomarkers for predicting functional outcomes in acute ischemic stroke patients with varying neurological severity.
Enrolled 37 patients with acute ischemic stroke divided by National Institutes of Health Stroke Scale (NIHSS) scores into Group 1 (NIHSS ≤15, n=20) and Group 2 (NIHSS >15, n=17).
Quantified stable serum metabolites of nitric oxide (NO) and endothelin-1 (ET-1) at hospital admission and on day 10.
Assessed functional outcomes pre- and post-treatment using absolute NIHSS scores and the Modified Rankin Scale (mRS) for disability.
Group 1 achieved significant reductions in both NIHSS (P=0.0013) and mRS (P<0.0001), whereas Group 2 improved only on the NIHSS (P=0.0012) with nonsignificant mRS changes.
Baseline ET-1 negatively correlated with NIHSS score in both Group 1 (R=–0.82, P=0.00023) and Group 2 (R=–0.55, P=0.00075).
Post-treatment mRS correlated negatively with NO (R=–0.50, P=0.00044) and ET-1 (R=–1.0, P=0.0074) in Group 1, but correlated positively with NO (R=0.55, P=0.0023) and ET-1 (R=0.33, P=0.04) in Group 2.

Structured PICO

Do NO and ET-1 serum concentrations predict functional outcome in patients with acute ischemic stroke?

Population

37 patients diagnosed with ischemic stroke and admitted to a multidisciplinary vascular center. Group 1 consisted of 20 patients with NIHSS scores 15, and Group 2 consisted of 17 patients with NIHSS scores 15.

Intervention

Quantitative assessment of stable nitric oxide (NO) and endothelin-1 (ET-1) metabolites in serum at admission and on day 10 of hospital stay

Outcome

Functional outcome assessed using the National Institutes of Health Stroke Scale (NIHSS) absolute values and the degree of disability measured by the Modified Rankin Scale (mRS) before and after baseline treatmentsurrogate

Baseline serum concentrations of ET-1 and NO correlate with functional recovery in acute ischemic stroke, suggesting their potential utility as prognostic biomarkers.

Cite This Study

Tynterova et al. (2023) studied this question.

synapsesocial.com/papers/6a6ff36da7fbea1e4407e5f9 https://doi.org/10.15360/1813-9779-2023-5-2354

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The Role of Endothelinergic and Nitroxidergic Reactions in Predicting the Functional Outcome in Patients with Ischemic Stroke of Different Severity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Role of Endothelinergic and Nitroxidergic Reactions in Predicting the Functional Outcome in Patients with Ischemic Stroke of Different Severity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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