What question did this study set out to answer?

To examine whether plasma endothelin-1 levels increase across acute and chronic phases of ischemic stroke and whether they correlate with stroke etiology, neurological scores, risk factors, or long-term outcomes.

March 1, 2000Stroke

Plasma Endothelin-1 Levels Neither Increase nor Correlate With Neurological Scores, Stroke Risk Factors, or Outcome in Patients With Ischemic Stroke

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Why the study?

Do plasma ET-1 levels increase or correlate with clinical outcomes in patients with ischemic stroke?

Population

101 consecutive patients with mild to moderate ischemic stroke and 101 sex- and age-matched control subjects

Design

Cohort

Follow-up

3 years

Authors

EHElena HaapaniemiUniversity of Helsinki TTTurgut TatlisumakWorcester Polytechnic Institute KHK. HamelAbbott Fund

Discussion

Member takes

Implication

Plasma ET-1 measurement adds no value in mild-moderate ischemic stroke; leaves open its role in severe cases or as a biomarker.

Key Points

To examine whether plasma endothelin-1 levels increase across acute and chronic phases of ischemic stroke and whether they correlate with stroke etiology, neurological scores, risk factors, or long-term outcomes.
Prospective, longitudinal study comparing 101 consecutive patients with ischemic stroke against 101 age- and sex-matched control subjects.
Plasma endothelin-1 levels were measured via sandwich-enzyme immunoassay on admission, 1 week, 1 month, and 3 months post-stroke alongside complete neurological evaluations and 3-year prognostic tracking.
Plasma endothelin-1 concentrations in patients were 2.4 ± 1.3 pg/mL on admission, 2.2 ± 1.4 pg/mL at 1 week, 2.1 ± 1.4 pg/mL at 1 month, and 2.1 ± 1.2 pg/mL at 3 months, differing negligibly from control levels of 2.2 ± 0.9 pg/mL.
No correlations emerged between endothelin-1 concentrations and stroke etiology, recurrence risk, neurological impairment scores, age, or sex, though levels correlated with warfarin use and body mass index.

Structured PICO

Do plasma ET-1 levels increase or correlate with clinical outcomes in patients with ischemic stroke?

Population

101 consecutive patients with mild to moderate ischemic stroke and 101 sex- and age-matched control subjects

Comparator

101 sex- and age-matched control subjects

Outcome

Plasma ET-1 levels on admission, 1 week, 1 month, and 3 months after strokesurrogate

Plasma endothelin-1 levels do not significantly increase or correlate with clinical outcomes or risk factors in patients with mild to moderate ischemic stroke.

Limitations

Plasma levels might not accurately reflect intracerebral concentrations
Excluded severely ill patients (only mild and moderately ill patients included)

Cite This Study

Haapaniemi et al. (2000) studied this question.

synapsesocial.com/papers/6a7847dc576efb0ddaf7fd29 https://doi.org/10.1161/01.str.31.3.720

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