Key result
Acute ischemic stroke is associated with markedly elevated plasma levels of ET-1 (3.5 vs 1.54 pg/mL, P<0.001) and ANP (110.9 vs 5.84 pg/mL, P<0.01) compared to normal volunteers.
Why the study?
Are plasma levels of endothelin-1 and atrial natriuretic peptide elevated in patients with acute ischemic stroke compared to normal volunteers?
Population
37 patients with acute ischemic stroke and age-matched normal volunteers
Design
Case-control
Follow-up
7 days
Authors
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May reflect acute vascular and cardiac stress in stroke; hypothesis-generating for biomarkers, requires prospective validation.
Case-Control (n=37)
Are plasma levels of endothelin-1 and atrial natriuretic peptide elevated in patients with acute ischemic stroke compared to normal volunteers?
Absolute Event Rate: 3.5% vs 1.54%
p-value: p=<.001
Acute ischemic stroke is associated with marked and sustained elevations in plasma endothelin-1 and atrial natriuretic peptide levels, with ET-1 correlating with neurologic deficit severity.
Estrada et al. (1994) conducted a case-control in Acute ischemic stroke (n=37). Acute ischemic stroke vs. Age-matched normal volunteers was evaluated on Plasma ET-1 levels at the onset of symptoms (pg/mL) (p=<.001). Acute ischemic stroke is associated with markedly elevated plasma levels of ET-1 (3.5 vs 1.54 pg/mL, P<0.001) and ANP (110.9 vs 5.84 pg/mL, P<0.01) compared to normal volunteers.