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February 1, 1973Journal of VirologyOpen Access

Effect of Viral Double-Stranded RNA on Protein Synthesis in Intact Cells

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Why the study?

Does viral double-stranded RNA inhibit protein synthesis in intact cells?

Population

Intact cells in culture

Design

Preclinical

Authors

BCB. Cordell-StewartUniversity of California, San FranciscoMTMilton W. TaylorIndiana University Bloomington

Discussion

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Implication

Hypothesis-generating for viral dsRNA selectivity in intact cells; extends cell-culture data but leaves open human disease relevance.

Structured PICO

Does viral double-stranded RNA inhibit protein synthesis in intact cells?

P
Population
Intact cells in culture
I
Intervention
Purified, noninfectious, double-stranded RNA of bovine enterovirus (a picornavirus)
O
Outcome
Cellular polypeptide synthesissurrogate

Viral double-stranded RNA specifically inhibits host cell protein synthesis without affecting viral protein translation in intact cells.

Cite This Study

Cordell-Stewart et al. (1973) studied this question.

synapsesocial.com/papers/6a6ff37bfebe604dd708c47chttps://doi.org/10.1128/jvi.11.2.232-237.1973
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Double-Stranded Viral RNA on Mammalian Cells in Culture1971 · 49 citations
  2. 2Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates1971 · 203 citations
  3. 3I. The Inhibition of Cellular Protein Synthesis in HeLa Cells after Infection with Active and Inactivated Poliovirus1971 · 7 citations
  4. 4Purification and Characterization of Poliovirus-induced Infectious Double-stranded Ribonucleic Acid1967 · 113 citations
  5. 5Characterization of ribonuclease-resistant RNA from poliovirus-infected HeLa cells.1965 · 46 citations