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May 1, 1999Arteriosclerosis Thrombosis and Vascular Biology

Nitric Oxide Production Is Reduced in Patients With Chronic Renal Failure

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Why the study?

Is whole body nitric oxide production impaired in patients with chronic renal failure compared to healthy controls?

Population

33 subjects total: 7 patients with chronic renal failure, 7 patients with familial hypercholesterolemia…

Comparison

Measurement of whole body NO production via… vs Matched healthy subjects.

Design

Cross-sectional

Authors

RWRobert WeverUniversity of CuraçaoPBPeter de BoerRadiotherapeutisch Instituut FrieslandMHMichel L. HijmeringIsala

Discussion

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Implication

May link reduced NO production to vascular risk in CRF; hypothesis-generating and requires prospective confirmation before guiding practice.

Structured PICO

Is whole body nitric oxide production impaired in patients with chronic renal failure compared to healthy controls?

P
Population
33 subjects total: 7 patients with chronic renal failure (CRF), 7 patients with familial hypercholesterolemia (FH) without clinical cardiovascular disease (nonsmokers), 5 cigarette smokers, and 14 healthy matched controls (7 matched to CRF, 7 matched to FH/smokers).
I
Intervention
Measurement of whole body NO production via intravenous infusion of [15N2]-arginine and LC-MS measurement of isotopic plasma enrichment of [15N]-citrulline.
C
Comparator
Matched healthy subjects.
O
Outcome
Whole body NO production (in vivo arginine-to-citrulline conversion).surrogate

Basal whole body NO production is significantly reduced in patients with chronic renal failure, providing a potential mechanism for their increased risk of atherosclerosis and endothelial dysfunction.

Cite This Study

Wever et al. (1999) studied this question.

synapsesocial.com/papers/6a6ff43787f9210571276635https://doi.org/10.1161/01.atv.19.5.1168
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase1995 · 543 citations
  2. 2Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.1990 · 1,021 citations
  3. 3Diagnosis and management of coronary artery disease in patients with end-stage renal disease on hemodialysis.1996 · 124 citations
  4. 4Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels1997 · 477 citations
  5. 5Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion1995 · 475 citations