Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 4, 2007BloodOpen Access

The role of Akt in the signaling pathway of the glycoprotein Ib-IX–induced platelet activation

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does Akt1/Akt2 deficiency or inhibition impair GPIb-IX-induced platelet activation?

Population

Mouse platelets deficient in PI3K effectors Akt1 and Akt2, and human platelets

Comparison

Akt inhibitor SH-6, PI3K inhibitors, or genetic… vs Untreated or wild-type platelets

Design

Preclinical

Authors

HYHong YinASAleksandra StojanovićNHNissim Hay

Discussion

Loading...

Member takes

Overview

Akt1/Akt2 inhibition may disrupt vWF-dependent platelet function; extends mechanistic insights but remains hypothesis-generating without human data.

Structured PICO

Does Akt1/Akt2 deficiency or inhibition impair GPIb-IX-induced platelet activation?

P
Population
Mouse platelets deficient in PI3K effectors Akt1 and Akt2, and human platelets
I
Intervention
Akt inhibitor SH-6, PI3K inhibitors, or genetic knockout of Akt1/Akt2
C
Comparator
Untreated or wild-type platelets
O
Outcome
Platelet aggregation and stable adhesion under flowsurrogate

Akt1 and Akt2 are essential for GPIb-IX-mediated integrin activation (inside-out signaling) via a cGMP-dependent pathway in platelets.

Cite This Study

Yin et al. (2007) studied this question.

synapsesocial.com/papers/6a6ff6b0660549caf2c4841dhttps://doi.org/10.1182/blood-2007-04-085514
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ32001 · 122 citations
  2. 2A Phosphoinositide 3-Kinase-AKT-Nitric Oxide-cGMP Signaling Pathway in Stimulating Platelet Secretion and Aggregation2006 · 121 citations
  3. 3Two Waves of Platelet Secretion Induced by Thromboxane A2 Receptor and a Critical Role for Phosphoinositide 3-Kinases2003 · 151 citations
  4. 4Molecular Analyses of the Platelet Glycoprotein Ib-IX-V Receptor1998 · 55 citations
  5. 5Role of Fc receptor γ-chain in platelet glycoprotein Ib–mediated signaling2001 · 126 citations