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November 21, 2024Journal of Clinical MedicineOpen Access

Postoperative Hemorrhage and Venous Thromboembolism in Patients with Pituitary Adenomas Under Acetylsalicylic Acid

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Why the study?

The impact of continued low-dose ASA on postoperative hemorrhage and the frequency of thromboembolic events after discontinuing ASA in patients undergoing pituitary adenoma surgery remain poorly understood.

Does perioperative low-dose ASA increase the risk of postoperative hemorrhage or thromboembolism in patients undergoing pituitary adenoma surgery?

Population

108 patients who underwent surgery for primary pituitary tumors

Comparison

Patients receiving low-dose ASA medication vs those who did not

Design

Retrospective study

Authors

NTNikolay TonchevAPAnatoli PinchukCDClaudia A. Dumitru

Discussion

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Member takes

Overview

Supports cautious perioperative ASA decisions in pituitary surgery; leaves open need for prospective trials before practice change.

Structured PICO

Does perioperative low-dose ASA increase the risk of postoperative hemorrhage or thromboembolism in patients undergoing pituitary adenoma surgery?

P
Population
108 patients who underwent surgery for primary pituitary tumors between January 2008 and January 2018 (from a larger retrospective cohort of 1862 brain tumor surgery patients).
I
Intervention
Low-dose acetylsalicylic acid (ASA) continued perioperatively.
C
Comparator
No low-dose ASA medication.
O
Outcome
Acute postoperative hemorrhage (POH) and thromboembolic events (venous thromboembolism or arterial pulmonary embolisms).safety

Perioperative continuation of low-dose ASA appears safe and is not associated with an increased rate of hemorrhagic complications following pituitary adenoma surgery.

Cite This Study

Tonchev et al. (2024) studied this question.

synapsesocial.com/papers/6a6ff719fe4101aa97dff779https://doi.org/10.3390/jcm13237020
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Also Consider

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