Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 15, 2024CancersOpen Access

Risk of Postoperative Hemorrhage After Glioma Surgery in Patients with Preoperative Acetylsalicylic Acid

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Patients with gliomas have an increased risk of spontaneous hemorrhage, while interrupting rising acetylsalicylic acid use is not always feasible perioperatively.

Does continuing acetylsalicylic acid perioperatively increase the risk of postoperative hemorrhage in patients undergoing glioma surgery?

Population

650 patients with various types of glial tumors who underwent surgery

Design

Retrospective cohort study

Authors

APAnatoli PinchukNTNikolay TonchevCDClaudia A. Dumitru

Discussion

Loading...

Member takes

Overview

Continuing ASA perioperatively may raise hemorrhage risk in glioma surgery; leaves open whether randomized trials will confirm safety.

Key Points

  • To evaluate the risk of postoperative hemorrhage and thromboembolic complications associated with continuing acetylsalicylic acid (ASA) perioperatively in patients undergoing glioma surgery.
  • Retrospective analysis of 650 patients undergoing surgery for glial tumors between 2008 and 2018, identified from an overall cohort of 7,149 intracranial surgery cases.
  • Patients were categorized into a no ASA impact group (no use or discontinued >7 days preoperatively) and an ASA impact group (continued ASA within 7 days preoperatively due to high cardiovascular or stroke risk).
  • Postoperative hemorrhage occurred in 2.7% of patients in the ASA impact group compared to 1.3% in the no ASA impact group (p = 0.098).
  • Overall, 50 of 650 patients developed a postoperative hemorrhage, with 10 requiring reoperation due to mass effect and neurological deterioration, demonstrating no statistically significant risk difference between groups.

Structured PICO

Does continuing acetylsalicylic acid perioperatively increase the risk of postoperative hemorrhage in patients undergoing glioma surgery?

P
Population
650 patients with various types of glial tumors who underwent surgery between 2008 and 2018
I
Intervention
Continued acetylsalicylic acid (ASA) use within seven days prior to operation
C
Comparator
No ASA use or discontinued ASA use more than seven days prior to surgery
O
Outcome
Postoperative hemorrhage (POH)safety

Perioperative continuation of acetylsalicylic acid in patients undergoing glioma surgery was not associated with a statistically significant increase in postoperative hemorrhage, suggesting it may be safe to continue in patients with high cardiovascular risk.

Limitations

  • Retrospective design

Cite This Study

Pinchuk et al. (2024) studied this question.

synapsesocial.com/papers/6a70b76c35aa2c282ce20892https://doi.org/10.3390/cancers16223845
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of perioperative aspirin use on hemorrhagic complications in elective craniotomy for brain tumors: results of a single-center, retrospective cohort study2019 · 46 citations
  2. 2Postoperative Acute Intracranial Hemorrhage and Venous Thromboembolism in Patients with Brain Metastases Receiving Acetylsalicylic Acid Perioperatively2024 · 3 citations
  3. 3Impact of acetylsalicylic acid in patients undergoing cerebral aneurysm surgery – should the neurosurgeon really worry about it?2021 · 10 citations
  4. 4Impact of Perioperative Acetylsalicylic Acid (ASA) Administration on Postoperative Intracranial Hemorrhage (pICH) and Thromboembolic Events in Patients with Intracranial Meningiomas2024 · 2 citations
  5. 5Postoperative Hemorrhage and Venous Thromboembolism in Patients with Pituitary Adenomas Under Acetylsalicylic Acid2024 · 3 citations