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September 7, 2017AgingOpen Access

Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging

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Why the study?

Does TLR4 deficiency reduce adipose tissue inflammation and improve glucose tolerance in aged mice?

Population

C57/Bl6 male mice (aged and normal controls)

Comparison

TLR4 deficiency vs Age-matched wild type mice

Design

Preclinical

Authors

AGAmiya K. GhoshUniversity of MichiganMOMartin O’BrienUniversity of MichiganTMTheresa MauSutter Health

Discussion

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Overview

Distinguishes aging-related from diet-induced adipose inflammation; leaves open Fet A-TLR4 role in age-associated metabolic dysfunction.

Structured PICO

Does TLR4 deficiency reduce adipose tissue inflammation and improve glucose tolerance in aged mice?

P
Population
C57/Bl6 male mice (aged and normal controls)
I
Intervention
TLR4 deficiency
C
Comparator
Age-matched wild type mice
O
Outcome
Adipose tissue inflammation and glucose tolerancesurrogate

TLR4 plays a significant role in promoting aging-associated adipose tissue inflammation, and its deficiency improves glucose tolerance in aged mice.

Cite This Study

Ghosh et al. (2017) studied this question.

synapsesocial.com/papers/6a6ff813febe604dd708c975https://doi.org/10.18632/aging.101288
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Also Consider

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