Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 5, 2021Immunity & AgeingOpen Access

Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice

View Full Paper
Ask AI
Bookmark
Share

Key result

TLR4 loss in aged mice improves cardiac performance and prevents hypertrophy versus wild-type.

  • P<0.05

Why the study?

Whether toll-like receptor 4 (TLR4) is involved in cardiovascular injury during the aging process had not been investigated.

Population

Mice

Comparison

TLR4 deficiency vs control in aged mice

Design

Animal study

Authors

HLHuan LiuSCShujuan ChuZWZhilin Wu

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for TLR4 inhibition in age-related cardiac dysfunction; human studies required before clinical consideration.

PICO

P
Population
Male wild-type and TLR4 knockout mice aged 3 and 24 months were evaluated for aging-related cardiovascular dysfunction, insulin resistance, and inflammation.
I
Intervention / Comparator
TLR4 knockout vs Wild-type mice
O
Primary Outcome
Cardiac performance and endothelium-dependent vascular relaxation, p=<0.05

Main Result

p-value: p=<0.05

Limitations

  • The study could not define the exact role of inflammation by regulating the levels of inflammatory factors.
  • TLR4 was knocked out from birth, so the effects of inhibiting TLR4 in a later life stage to reverse existing aging-related cardiovascular dysfunction remain unknown.

Cite This Study

Liu et al. (2021) studied Aging-related cardiovascular dysfunction. TLR4 knockout vs. Wild-type mice was evaluated on Cardiac performance and endothelium-dependent vascular relaxation (p=<0.05). Loss of TLR4 in aged mice significantly improved cardiac performance, prevented cardiac hypertrophy, and restored endothelium-dependent vascular relaxation (p<0.05) compared to wild-type aged mice.

synapsesocial.com/papers/6aa1fec757affa4c5d46ebd2https://doi.org/10.1186/s12979-021-00251-y
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting the Toll-Like Receptor 4 Ameliorates Heart Failure in Aged Mice by Inhibiting the Formation of Neutrophil Extracellular Traps2026 · 1 citations
  2. 2Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging2017 · 59 citations
  3. 3Elevated Expression of TLR2 in Aging Hearts Exacerbates Cardiac Inflammatory Response and Adverse Remodeling Following Ischemia and Reperfusion Injury2022 · 16 citations
  4. 4TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes2012 · 98 citations
  5. 5Toll-like receptor 2 modulates age-associated insulitis and fibrotic remodeling of Langerhans islets2026