Why the study?
Does estrogen receptor beta deficiency affect ventricular repolarization and automaticity in female mice after myocardial infarction?
Population
Female mice with and without chronic anterior myocardial infarction
Comparison
Estrogen receptor beta deficiency and estrogen… vs Wild-type mice and noninfarcted mice
Design
Preclinical
Follow-up
6 weeks
Authors
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ERβ deficiency alters post-MI repolarization and ectopy in mice; leaves open relevance to human arrhythmia risk after infarction.
Does estrogen receptor beta deficiency affect ventricular repolarization and automaticity in female mice after myocardial infarction?
Estrogen receptor beta deficiency in female mice leads to prolonged ventricular repolarization and decreased ventricular automaticity after myocardial infarction, suggesting a role for ERbeta in post-MI electrophysiological remodeling.
Korte et al. (2005) studied this question.
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