April 1, 1987Annual Review of Immunology
Vaccinia Virus Expression Vectors
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Discussion
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Implication
Review reveals the functional and molecular characteristics of exhausted CD8 T cells in chronic diseases, suggesting new avenues for viral vector immunotherapies.
Key Points
- To characterize exhausted CD8 T cell lineages, their functional impairments, and the utility of vaccinia virus expression vectors in dissecting T cell biology.
- Evaluation of exhausted CD8 T cell developmental trajectories and phenotypes in chronic infections and cancer models.
- Application of recombinant vaccinia virus expression vector systems to assess antigen-specific T cell effector functions and regulation.
- Exhausted CD8 T cells display progressive loss of effector functions and sustained expression of inhibitory surface receptors during persistent antigen stimulation.
- Recombinant vaccinia virus expression systems provide robust delivery tools to probe effector mechanisms and modulate T cell exhaustion states.
Cite This Study
Moss et al. (1987) studied this question.