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January 1, 1997HypertensionOpen Access

The Link Among Nitric Oxide Synthase Activity, Endothelial Function, and Aortic and Ventricular Hypertrophy in Hypertension

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Population

Spontaneously hypertensive rats and Dahl salt-sensitive rats matched for blood pressure and age, along with…

Comparison

Antihypertensive therapy consisting of an… vs Normotensive counterparts and untreated…

Design

Preclinical

Authors

HHHiroshi HayakawaMuseum of Natural and Environmental History, ShizuokaLRLeopoldo RaijVascular Medicine

Discussion

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Overview

May explain variable hypertensive end-organ damage; leaves open cNOS modulation as therapeutic target pending human studies.

Structured PICO

P
Population
Spontaneously hypertensive rats (SHR) and Dahl salt-sensitive (DS) rats matched for blood pressure and age, along with their normotensive counterparts (Wistar-Kyoto rats and normotensive DS rats).
I
Intervention
Antihypertensive therapy consisting of an angiotensin-converting enzyme inhibitor (perindopril) and a diuretic (indapamide) in DS rats.
C
Comparator
Normotensive counterparts (Wistar-Kyoto rats and normotensive DS rats) and untreated hypertensive rats.
O
Outcome
Left ventricular (LV) and aortic constitutive nitric oxide synthase (cNOS) activity, LV hypertrophy (LV weight/body weight), and aortic hypertrophy (aortic weight/length).surrogate

Upregulation of vascular cNOS activity appears to have a protective cardiovascular homeostatic role in hypertension, potentially explaining variable end-organ disease severity among individuals with similar blood pressure levels.

Cite This Study

Hayakawa et al. (1997) studied this question.

synapsesocial.com/papers/6a6ffc83f44fa9f079dd80cdhttps://doi.org/10.1161/01.hyp.29.1.235
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular Structure and Expression of Endothelin-1 Gene in L-NAME–Treated Spontaneously Hypertensive Rats1996 · 78 citations
  2. 2Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress1995 · 293 citations
  3. 3Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.1994 · 941 citations
  4. 4Nitric oxide synthase in cultured endocardial cells of the pig1991 · 157 citations
  5. 5Mechanisms for altered endothelium-dependent vasorelaxation in isolated kidneys from experimental hypertensive rats1993 · 74 citations